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Laure Malclès was born in Paris on May 8, 1911.
She met the Belgian engraver Frans Masereel (1889-1972) during the Second World War and took part in his trip to China in 1958, also accompanied by gallery owner and art publisher Pierre Vorms (1903-1986). A few months after the death of his first wife, Pauline Imhoff, Frans Masereel married Laure Malclès on 14 January 1969. The latter was then given the name Malclès-Masereel. The couple lives between a main house in Avignon and an apartment-workshop in Nice.
Malclès-Masereel is part of the permanent collections of the Museum of Modern Art of the City of Paris and the City of Brussels, among others.
Laure Malclès-Masereel died on September 21, 1981 in Avignon.